![]() ![]() “The exciting message is that because the pathophysiology is so similar, the last couple of decades in cancer therapy-related research can guide us to treatments that may help COVID brain fog. The overlap between what happens in COVID-19’s cognitive aftermath and chemo brain, as it’s colloquially known, could be good news for patients because it may speed research on treatments, Monje said. ![]() The study’s lead authors are Anthony Fernandez-Castaneda, PhD, a postdoctoral scholar at Stanford Anna Geraghty, PhD, an instructor of neurology at Stanford and Peiwen Lu, PhD, and graduate student Eric Song, both of Yale. The drug guanfacine is commonly prescribed and well tolerated. A Possible Mechanism Behind Brain Fog Researchers supported by NINDS and several other NIH institutes found a similar inflammatory response to SARS-CoV-2 in both the brain and spinal cord even in mild cases of COVID-19. ![]() Monje shares senior authorship of the study with Akiko Iwasaki, PhD, professor of immunology and of molecular, cellular and developmental biology at Yale University. My advice to those with brain fog is to discuss this experimental treatment with your doctor. “We found that even mild COVID can cause prominent inflammation in the brain that dysregulates brain cells and would be expected to contribute to cognitive impairment,” said Michelle Monje, MD, PhD, professor of neurology and neurological sciences. The findings may help guide treatments for cognitive effects of COVID-19, the scientists said. The discovery, described in a paper that published online June 12 in Cell, relied on studies of mice with mild SARS-CoV-2 infection and postmortem human brain tissue collected early in the pandemic. Researchers chasing long COVID cures are eager to learn whether the drug can offer similar benefits to millions suffering from pain, fatigue and brain fog months after a coronavirus. SARS-CoV-2, the virus behind COVID-19, doesn’t usually make it into the brain directly. One leading theory that I think is very probable. Brain fog after COVID-19 is biologically similar to cognitive impairment caused by cancer chemotherapy, something doctors often refer to as “chemo brain.” In both cases, excessive inflammation damages the same brain cells and processes, according to research led by Stanford University School of Medicine. Februat 7:00 am A tussle with COVID-19 can leave people’s brains fuzzy. Of 56 longhaulers, six months after getting COVID, two-thirds still reported persistent neurological symptoms. Early reports of brain fog and persistent cardiac symptoms in COVID-19 survivors prompted the Columbia researchers to investigate how certain molecules. ![]()
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